The FASEB Journal Volume 16, Number 5 March 22, 2002 Experimental Biology 2002 New Orleans, Louisiana April 20-24, 2002 742.16 Effect Of Hydroxycitric Acid On Weight Loss, Body Mass Index And Plasma Leptin Levels In Human Subjects H.G. Preuss, D. Bagchi, C.V.S. Rao, B.W. Echard, S. Satyanarayana, M. Bagchi, Dept of Physiology and Biophysics, Georgetown University Medical Center, Washington, DC; Dept of Pharmacy Sciences, Creighton University School of Pharmacy and Allied Health Professions, Omaha NE; Dept of General Medicine, ASR Academy of Medical Sciences, Elluru, AP India; Dept of Pharmacy, Andhra University, Visakhapatnam, AP India A growing body of evidence indicates that Garcinia cambogia-derived (-)-hydroxycitric acid (HCA-SX, Super CitriMax) is efficacious in weight management by curbing appetite and inhibiting fat synthesis. HCA was shown to suppress appetite by increasing serotonin release and may possess antidepressant properties similar to fluoxetine. However, the mechanistic aspects of weight management by HCA-SX are not completely understood. We examined the effects of HCA-SX in 48 moderately obese subjects in a randomized, double-blind, placebo-controlled study. The two groups received either placebo tid or HCA-SX (2,800 mg tid) 30 min. before meals for 8 weeks. Both groups received approximately 2,000 kcal diet per day and participated in a walking exercise program supervised by a trained exercise specialist. Approximately 3.3% and 4.8% loss in body weight was observed following supplementation with HCA-SX at the end of 4 and 8 weeks, respectively, in the HCA-SX supplemented group, and 1.6% and 2% respectively, in the placebo group. Plasma leptin levels were assessed as an index of obesity gene. Plasma leptin levels were also reduced by 18.8% and 40% at the end of 4 and 8 weeks, respectively. Triglyceride, LDL and total cholesterol levels were marginally reduced following supplementation with HCA-SX. We conclude that HCA-SX can serve as a novel tool in weight management by modulating the obesity gene. Amino Acid Supplements.

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