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The FASEB Journal
Volume 16, Number 5 March 22, 2002
Experimental Biology 2002
New Orleans, Louisiana
April 20-24, 2002
742.16
Effect Of Hydroxycitric Acid On Weight
Loss, Body Mass Index And Plasma Leptin Levels In Human Subjects
H.G. Preuss, D. Bagchi, C.V.S. Rao, B.W. Echard, S.
Satyanarayana, M. Bagchi, Dept of Physiology and Biophysics,
Georgetown University Medical Center, Washington, DC; Dept of
Pharmacy Sciences, Creighton University School of Pharmacy and
Allied Health Professions, Omaha NE; Dept of General Medicine, ASR
Academy of Medical Sciences, Elluru, AP India; Dept of Pharmacy,
Andhra University, Visakhapatnam, AP India
A growing body of evidence indicates that Garcinia cambogia-derived
(-)-hydroxycitric acid (HCA-SX, Super CitriMax) is efficacious in
weight management by curbing appetite and inhibiting fat
synthesis.
HCA was shown to suppress appetite by increasing
serotonin release and may possess antidepressant properties
similar to fluoxetine. However, the mechanistic aspects of weight
management by HCA-SX are not completely understood. We examined
the effects of HCA-SX in 48 moderately obese subjects in a
randomized, double-blind, placebo-controlled study.
The two groups
received either placebo tid or HCA-SX (2,800 mg tid) 30 min.
before meals for 8 weeks. Both groups received approximately
2,000 kcal diet per day and participated in a walking exercise
program
supervised by a trained exercise specialist.
Approximately
3.3% and 4.8% loss in body weight was observed following
supplementation with HCA-SX at the end of 4 and 8 weeks,
respectively, in the HCA-SX supplemented group, and 1.6% and
2% respectively, in the placebo group.
Plasma leptin levels
were assessed as an index of obesity gene. Plasma leptin
levels were
also reduced by 18.8% and 40% at the end of 4 and 8 weeks,
respectively.
Triglyceride, LDL and total cholesterol levels
were marginally reduced following supplementation with
HCA-SX. We
conclude that HCA-SX can serve as a novel tool in weight
management by modulating the obesity gene.
Amino
Acid Supplements.
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