BioShape™ BioShape™ has been developed as an advanced concept for weight management. Bioshape contains a proportioned amount of essential amino acids to provide the body the capability for making protein necessary for health and firm musculature during a weight management program. In addition, Super Citrimax™ Full Strength has been added to the formula. This is a unique patented blend of two historically used Ayurvedic herbs, Garcinia cambogia and Gymnema sylvestre, plus a superior form of chromium, all extensively researched for optimizing fat and sugar metabolism.1-5 BioShape contains the highest quality, vegetable source, crystalline amino acids that are 99% absorbed within 20 minutes to perform maximally as a protein supplement without adding additional fats or calories to your daily diet. Essential amino acids are necessary for building protein and muscle throughout the body. Common protein sources such as various meats, eggs, milk and cheeses are often high in fats and cholesterol, and are not easily digested or assimilated. Taking essential amino acids during a weight management program helps assure that you are getting quality protein for keeping your body in shape, strong and healthy. The Super Citrimax Full Strength blend added to BioShape contains an extract of Garcinia cambogia. The active compound, hydroxycitric acid (HCA), has been studied for its effects inhibiting fat production, activating the oxidation of fats in the liver and accelerating the burning of excess fat in the body.1,2,6,7 Clinical studies have shown Super Citrimax Full Strength when taken as directed to promote: 6,7 A decrease in leptin levels with a reduction in body weight An increase in serotonin levels, which helps curb appetite The inhibition of fat synthesis An increase in fat burning Healthy blood lipid levels The reduction of Body Mass Index (indicator of obesity health risk) Conditionally Essential Amino Acids Peer reviewed research has shown that there are nine essential and two conditionally essential amino acids and these have been added to the BioShape formula.8,9,10 Under certain situations your body cannot always make the needed amounts of arginine, glutamine or histidine. When you exercise, become mentally or physically stressed, if you are over 55 years, or if you have a medical condition or are recovering from an illness you need these amino acids. Without enough histidine or glutamine the body actually breaks down muscle tissue to get them. 8,9 Glutamine is also critical for the immune system during illness or recovery.10 Arginine is also a conditionally essential amino acid.11 Researchers reported, "The effect of L-arginine in treating many common health problems is unique among amino acids and offers great promise for improved health and well being.''12 The authors state that arginine is beneficial in improving cardiovascular, reproductive, pulmonary, renal, GI, liver and immune functions.12   References 1.) Watson JA, Pang M, LowensteinJM. Tricarballylate and hydroxycitrate: substrate and inhibitor of ATP citrate oxaloacetate lyase. Arch Biochem Biophysi 1969;135:209-217. 2.) Rao RN, Sakariah KK. Lipid-lowering and antiobesity effect of hydroxy-citric acid. J Nutr Res 1988,8,209-212. 3.) Ye W, Liu X, Zhang Q, Che CT, Zhao S. Antisweet saponins from Gymnema sylvestre. J Nat Prod 2001,64(2)232-5 4.) Persaud SJ, Al-Majed H, Raman A, Jones PM. Gymnema sylvestre stimulates insulin release in vitro by increased membrane permeability. 5.) Evans GW. Effect of Chromium Picolinate on insulin-controlled parameters in humans. J Biosoc. Med. Res 1989,11.163-180. 6.) Bagchi D, Preuss HG, Ohia SE, Rao CVS, Satyanarayana S, Bagchi M. Weight management and mechanism of appetite suppression by a novel, natural extract of (-)-Hydroxycitric acid. International Scientific Conference on Complimentary, Alternative & Integrative Medicine Research-Harvard University, 9, Abs. 141, April 12-14, 2002. 7.) Preuss HG, Bagchi D, Rao CVS, Echard BW, Satuanarayana S, Bagchi M. Effect of Hydroxycitric Acid on Weight Loss, Body Mass Index and Plasma Leptin Levels in Human Subjects, FASEB Journal, 16A1020, Abs. 742,16,2002. 8.) Kopple JD, Swendseid MD. Evidence that Histidine is an Essential Amino Acid in Normal and Chronically Uremic Man. Journal of Clinical Investigation 1975, 55, 881-891. 9.) Boelens, Petra G. Glutamine Alimentation in Catabolic States. Journal of Nutrition 2001, 131 (9S) 2569S-2577S. 10.) Andrews FJ, Griffiths RD. Glutamine: essential for immune nutrition in the critically ill. British J of Nutrition 2002, 87 Supp 1:S3-8. 11.) Durante W. Regulation of L-arginine transport and metabolism in vascular smooth muscle cells. Cell Biochem Biophysics 2001,35 (1);19-34. 12.) Wu G, Meininger CJ, et. al. Arginine nutrition in development, health and disease. Curr Opin Clin Nutr Metab Care 2001,3,1 59-66. New Bioshape™ New Bioshape™ is an improved amino acid formulation. It now contains the highest quality, vegetable sourced, crystalline amino acids to perform even better as a protein supplement for your personal weight management program. Peer reviewed research has shown that there are nine essential and two conditionally essential amino acids. These 3 additional amino acids have been added to New Bioshape for maximizing the benefits to your body. To make it an even better dietary supplement for an effective weight management program, Super Citrimax Full Strength™ has been added. This is a unique patented blend of herbs and a natural form of chromium that has been shown in clinical trials to be effective in weight management. It contains two important Ayurvedic herbs Garcinia cambogia and Gymnema sylvestre leaves both researched and historically used for optimizing fat and sugar metabolism. We're taking care of you! Why would I take an amino acid supplement? To assure that you are getting the required amounts of amino acids to create important proteins of the body that function in building muscle mass, heart muscle, skin, connective tissue, hormones, enzymes and immune proteins. Obtaining a good source of essential amino acids is crucial to an effective weight management program. Although it provides the same essential amino acids as a protein source such as meat, eggs or milk, it has essentially no calories and no fat. Under certain situations your body needs additional amino acids. You cannot always make the needed amounts of arginine, glutamine or histidine when you exercise, become mentally or physically stressed, if you are over 55 years, or if you have a medical condition or are recovering from an illness. For these reasons all eleven of these amino acids have been included in the formula of New Bioshape. Why has Bioshape been Improved? World-class protein scientists advised RBC that histidine should be included as essential, as reported in 1975 in the Journal of Clinical Investigation. Without histidine the body actually breaks down protein stores1. This is why it is important to add it to a formula designed to help with a weight and fat reduction diet program. Body firmness is retained.   In Journal of Nutrition, 2001 the authors state that glutamine should be reclassified as a conditionally essential amino acid. After stress or exercise your body's need for glutamine increases. Without enough glutamine the body will break down muscle tissue to get it2. It is also critical for the immune system during illness or recovery.3   Arginine is also a conditionally essential amino acid. It has been found to be important for the smooth muscles of the cardiovascular system, providing protection to the heart.4,5 In addition, researchers reported, "The effect of L-arginine in treating many common health problems is unique among amino acids and offers great promise for improved health and well being.''6 The authors state that arginine is beneficial in improving cardiovascular, reproductive, pulmonary, renal, GI, liver and immune functions6.   Tryptophan has been prohibited in both U.S. and Canada, therefore it had to be removed from Bioshape. However, 5-Hydroxytryptophan (5-HTP) has been added as a precursor instead to provide the principle function of tryptophan to make serotonin, known for its appetite-suppression and influence on food choice effects 7,8. Virtually all sources of protein in your diet provide sufficient tryptophan for its other minor functions. New Bioshape is as quickly digested and absorbed as it was before: Protein in meat, poultry, or fish takes hours to digest, overworks the digestive system and delays the delivery of amino acids.   The free-form soluble amino acids in Bioshape are 99% digestible and are absorbed into the blood stream within twenty minutes.9   Within approximately twenty minutes these bodybuilding amino acids are ready to be utilized for protein synthesis.9 What the experts say about amino acid utilization: The essential amino acid index of New Bioshape is 227% greater than egg albumin, which is considered one of the best dietary proteins.   Amino acids are water soluble and of vegetable or non animal origin   The absorption and utilization of crystalline amino acids have been well researched in humans and animals for many years. Well-published experts using labeled crystalline amino acids have found that 80%-90% (fed vs. fasting states) of absorbed amino acids are available for protein synthesis.10,11   Present day researchers consider the methods pertaining to measuring NNU and nitrogen balance as out-dated. NNU required feces sampling which was not always accurate. Research using labeled amino acids provides more accurate assessment of where and how they are utilized by the body.10,11   Catabolytes or by-products from amino acid utilization depend on the individual's diet, exercise program and needs. Excess nitrogen is always excreted through the kidneys. Drink plenty of water.   Experts agree that there is no concrete evidence that assures some absolute amino acid ratio in a healthy dietary formula. New Bioshape has been formulated to provide the body with the essential amino acids it needs in order to optimally build muscle tissue, during and after exercise and to supply the right amount of protein for an optimal weight loss program. Take Bioshape to help shape your body and support fat loss not muscle loss. Bioshape is a protein supplement not a substitute. Continue to eat other good protein sources to obtain dietary tryptophan such as nuts, beans, peas, soy, turkey, fish, meats, dairy products or take Spirulina. New Bioshape™ now contains Garcinia, a fat reducing herb!   New Bioshape provides a standardized extract from the berry of the evergreen tree, Garcinia cambogia, used for centuries as an Ayurvedic Indian herb and grown in southern India.   In several recent clinical studies, Garcinia has been shown to effectively and safely increase the burning of fatty acids, and to reduce fat formation in humans12,13.   The active ingredient in the Garcinia berry is -hydroxycitrate (-HCA), which competes for the enzyme that builds fat molecules in the cells12   HCA blocks fatty acid biosynthesis and activates the oxidation of fat in the liver and adipose tissues13   HCA accelerates the burning of excess fat in the body   HCA has an appetite suppressive affect that is not centered in the brain, as is usual for most appetite-suppressive ingredients, but is centered in the liver   HCA supports the balance of glucose from the liver making you feel less hungry.   Findings from studies indicate that HCA may be effective in helping to normalize lipid (free fatty acids) levels14,15.   The New Bioshape Weight Management Plan is simple, effective, and healthy Why has the herb Gymnema sylvestre been added? Helps curb the cravings for sugar16 Also called gur-mar (sugar reducing). Has an active ingredient which helps neutralize excess sugar Scientific evidence shows support that fats are less absorbed in the intestinal tract when consuming Gymnema sylvestre17 Studies show that insulin utilization is enhanced beneficially by using this herb.18 Clinical investigations show that Chromium is effective in supporting insulin activity and weight control when combined with the herbs. A blend containing both Garcinia cambogia and Gymnema sylvester have shown enhanced effective weight management with the addition of chromium. Chromemate™ is a safe chromium source added to the Super Citrimax blend to enhance the weight management benefits of the formula. Chromium has been extensively researched and is required for sugar and fat metabolism19. The optimal effective amount has been added to enhance the benefits to your personal weight management program. How to take Bioshape for Weight Management and for Supporting Muscle Strength   Daily requirements for protein vary by age, weight, and health. An adult requires about 1/3 gram of protein per pound of body weight. For example a 140-pound person would need 50 grams (or less than 2 ounces) of protein per day. However, the protein you consume in vegetables, fish, meat, or poultry may not be readily digestible or provide a high NPU (Net Protein Utilization). New Bioshapes acts as a supplement to the protein in your normal diet. It provides you a complete range of easily digestible amino acids in ideal ratios, with a high NPU. Take four caplets of Bioshape with a glass of water ½ hour before your largest meal. Then take 3 caplets with a glass of water ½ hour before your other meals. This will provide you 10 grams of pure, high quality amino acids in addition to the recommended amount of the other herbs and chromium to assure the effectiveness of the ingredients acting together for optimal fat and sugar metabolism. Eat a modest diet of at least 30% calories from protein, 40% from carbohydrates, and no more than 30% from fat. Include fresh raw fruits, vegetables, and green foods. Exercise at least 30 minutes and at least three times per week. References 1.) Kopple JD, Swendseid MD. Evidence that Histidine is an Essential Amino Acid in Normal and Chronically Uremic Man. Journal of Clinical Investigation 1975, 55, 881-891. 2.) Boelens, Petra G. Glutamine Alimentation in Catabolic States. Journal of Nutrition 2001, 131 (9S) 2569S-2577S. 3). Andrews FJ, Griffiths RD. Glutamine: essential for immune nutrition in the critically ill. British J of Nutrition 2002, 87 Supp 1:S3-8. 4.) Durante W. Regulation of L-arginine transport and metabolism in vascular smooth muscle cells. Cell Biochem Biophysics 2001,35 (1);19-34. 5). Yan Y, Davani S, et al. Effects of L-arginine administration before cardioplegic arrest on ischemia-reperfusion injury. Ann Thorac Surg, 2001, 72,6;1985-90. 6.) Wu G, Meininger CJ, et. al. Arginine nutrition in development, health and disease. Curr Opin Clin Nutr Metab Care 2001,3,1 59-66. 7.) Shils M, Young VR. Modern Nutrition in Health and Disease 7th Edition. Lea and Febiger, 1988. Philadelphia PA. 8.) Lehninger AL , Nelson DL, Cox MM. Principles of Biochemistry 2nd Edition. 1997. Worth Publishers, New York, NY. 9.) Chung TK, Baker DH. Apparent and True Amino Acid Digestibility of a crystalline amino acid mixture and of casein: Comparison of values obtained with ileal-cannulated pigs and cecectomized cockerels. J Animal Science 1992, 70;3781-3790. 10.) Blackburn GL, Grant JP, Young VR. Amino Acids Metabolism and Medical Applications, 1983. John Wright-PSG Inc. Boston, MA. 11.) Mathews D, Downey RS. Measurement of urea kinetics in humans: A validation of stable isotope tracer methods. Am J Physio Endocrinol Metab 247;E634-E638, 1984. 12.)WatsonJA, PangM, LowensteinJM. Tricarballylate and hydroxycitrate: substrate and inhibitor of ATP citrate oxaloacetate lyase. Arch Biochem Biophysi 1969;135:209-217. 13). Rao RN, Sakariah KK. Lipid-lowering and antiobesity effect of hydroxy-citric acid. J Nutr Res 1988,8,209-212. 14.) Sullivan AC, Triscari J, Speigel HE. Metabolic regulation as a control for lipid disorders. II I influence of (-)-hydroxycitrate on genetically and experimentally induced hypertriglyceridemia in the rat. Am J Clin. Nutr 1977,30;777-784. 15.) Berkout TA, Havekes LM, Pearce NJ, Groot PHE. The effect of (-)-hydroxycitrate on the activity of the low-density-lipoprotein receptor and 3-hydroxy-3-methyglutaryl-coA reductase. Biochem J 1990,272;181-186. 16.) Ye W, Liu X, Zhang Q, Che CT, Zhao S. Antisweet saponins from Gymnema sylvestre. J Nat Prod 2001,64(2)232-5. 17.) Shigematsu N, Asano R, Shimosaka M, Okazaki M. Effect of administration with the extract of Gymnema sylvestre R. Br leaves on lipid metabolism in rats. Biol Pharm Bull 2001, 24;6;713-7. 18. Persaud SJ, Al-Majed H, Raman A, Jones PM. Gymnema sylvestre stimulates insulin release in vitro by increased membrane permeability. 19. Evans GW. Effect of Chromium Picolinate on insulin-controlled parameters in humans. J Biosoc. Med. Res 1989,11.163-180

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